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ABO blood group, secretor status and detection of Helicobacter pylori among patients with gastric or duodenal ulcers

Published online by Cambridge University Press:  15 May 2009

A. Mentis ,
C. C. Blackwell ,
D. M. Weir ,
C. Spiliadis ,
A. Dailianas  and
N. Skandalis
A. Mentis
Affiliation:
Hellenic Institute Pasteur, Athens
C. C. Blackwell*
Affiliation:
Department of Medical Microbiology, The Medical School, University of Edinburgh, Edinburgh
D. M. Weir
Affiliation:
Department of Medical Microbiology, The Medical School, University of Edinburgh, Edinburgh
C. Spiliadis
Affiliation:
Department of Gastroenterology, General Hospital of Athens, Athens
A. Dailianas
Affiliation:
Department of Gastroenterology, General Hospital of Athens, Athens
N. Skandalis
Affiliation:
Department of Gastroenterology, General Hospital of Athens, Athens
*
* Corresponding author.
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Patients (454) referred for gastroscopy to the General Hospital of Athens were examined to determine (1) if non-secretors were over-represented among patients with ulcers and (2) is there was an association with ABO blood group or secretor status and carriage of Helicobacter pylori.

Compared with the local population, among patients with either gastric ulcer (51) or duodenal ulcer (96) there was a significant increase in the proportion of those who were blood group O (P < 0·025); however, there were no significant differences in the proportions of non-secretors. H. pylori was identified in 62 % of the 454 patients: 59·5 % of those without evidence of ulcers; 62·5 % of those with gastric ulcer; 88% of those with duodenal ulcer (P < 0·0005). These bacteria were cultured more often and in higher numbers from patients with duodenal ulcer (P < 0·025). There was no association between ABO blood group and prevalence of H. pylori. The prevalence of H. pylori among non-secretors with gastric ulcer (12·5%) was significantly lower than that for non-secretors with duodenal ulcer (100%) (P < 0·0005). This was not observed for secretors.

Type
Special Article
Information
Epidemiology & Infection , Volume 106 , Issue 2 , April 1991 , pp. 221 - 229
Copyright
Copyright © Cambridge University Press 1991

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