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Apoptosis in Helicobacterpylori-Associated Gastric and Duodenal Ulcer Disease Is Mediated via the Fas Antigen Pathway

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Abstract

Increased mucosal apoptosis is seen in H.pylori-infected gastric tissue; however, the precisemechanism by which this organism triggers programmedcell death is poorly understood and is investigated in this study. One pathway for induction ofapoptosis is the Fas Ag pathway. Normal gastric andsmall bowel tissue express low levels of Fas antigen andnondetectable levels of Fas ligand. Consequent to H. pylori infection, The re is elevated expressionof Fas antigen in mucosal cells concurrent with Fasligand expressing lymphocytes. This prompted us toinvestigate the potential role of Fas in mediating H. pylori-related apoptosis. It has been shownthat inflammatory cytokines are abundant in H.pylori-infected tissue and that cytokines regulate theexpression of Fas Ag in various tissue types. Using cell culture, we examine The role of specificinflammatory cytokines in activating this pathway. Thiscommunication presents the first evidence to implicatethe Fas pathway in mediating apoptosis in H.pylori-associated gastric and duodenal ulcer disease.

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Houghton, J., Korah, R.M., Condon, M.R. et al. Apoptosis in Helicobacterpylori-Associated Gastric and Duodenal Ulcer Disease Is Mediated via the Fas Antigen Pathway. Dig Dis Sci 44, 465–478 (1999). https://doi.org/10.1023/A:1026628601284

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  • DOI: https://doi.org/10.1023/A:1026628601284

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