Abstract
ALTHOUGH the amount of IgA in serum is small compared with the amount of IgG, IgA is predominant in secretory fluids such as colostrum, saliva, nasal fluid and tears1–3. IgA from the colostrum and saliva4 has a higher sedimentation constant (11S) than serum IgA (7S), and 11S colostral IgA has additional antigenic determinants with specificities which are not present in serum IgA. In addition to the heavy (α) and light chains present in the molecule of serum IgA, colostral IgA has another protein component—the transport piece5.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Tomasi, jun., T. B., and Zigelbaum, S., J. Clin. Invest., 42, 1552 (1963).
Remington, J. S., Vosti, K. L., Lietze, A., and Zimmerman, A. L., J. Clin. Invest., 43, 1613 (1964).
Chodirker, W. B., and Tomasi, jun., T. B., Science, 142, 1080 (1963).
Tomasi, jun., T. B., Tan, E. M., Solomon, A., and Prendergast, R. A., J. Exp. Med., 121, 101 (1965).
South, M. A., Cooper, M. D., Wollheim, F. A., Hong, R., and Good, R. A., J. Exp. Med., 123, 615 (1966).
Oser, B. L., Practical Physiological Chemistry, fourteenth ed., 368 (McGraw-Hill, New York, 1965).
Cebra, J. J., and Robins, J. B., J. Immunol., 97, 12 (1966).
Faarvang, H. J., Proc. Soc. Exp. Biol. and Med., 98, 89 (1958).
Kueppers, F., and Bearn, A. G., Proc. Soc. Exp. Biol. and Med., 121, 1207 (1966).
Chamberlain, A. G., Perry, G. C., and Jones, B. E., Nature, 207, 429 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SHIM, BS., KANG, YS., KIM, WJ. et al. Self-protective Activity of Colostral IgA against Tryptic Digestion. Nature 222, 787–788 (1969). https://doi.org/10.1038/222787a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/222787a0
This article is cited by
-
Mucosal defense against enteric pathogens
The Indian Journal of Pediatrics (1983)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.