Abstract
MANY chemicals are activated to carcinogens and mutagens by oxidative metabolism to alkylating agents1. Ascorbic acid has been reported to protect against tumour induction in mice by 3-hydroxyanthranilic acid, which induced bladder tumours2 and 7,12-dimethylbenzanthracene plus croton oil which induced skin tumours3. Ascorbic acid can also prevent the formation of carcinogenic N-nitroso compounds from nitrite and amines, in vivo4 and in vitro5. I report here that mutagenesis by two preformed N-nitroso compounds is effectively inhibited by ascorbic acid.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Miller, J. A. Cancer Res. 30, 559–576 (1970).
Schlegal, J. U., Pipkin, G. E., Nishimura, R. & Schultz, G. N. J. Urol, 103, 155–159 (1970).
Shamberger, R. J. J. natn. Cancer Inst. 48, 1491–1495 (1972).
Kamm, J. J., Dashman, T., Conney, A. H. & Burns, J. J. Ann. N.Y. Acad. Sci. 258, 169–174 (1975).
Mirvish, S. S. Ann. N.Y. Acad Sci. 258, 175–180 (1975).
Druckery, H., Preussman, R., Ivankovic, S. & Schmaehl, D. Z. Krebsforschung 64, 103–210 (1967).
Magee, P. N. & Barnes, J. M. Adv. Cancer Res. 10, 163–246 (1967).
Magee, P. N., Montesano, R. & Preussman, R. in Am. Chem. Soc. Monograph, Chemical Carcinogens (ed. Searle, C.) (1976).
Loveless, A. Nature 223, 206–207 (1969).
Nicoll, J. W., Swann, P. F. & Pegg, A. E. Nature 254, 261–262 (1975).
Edgar, J. A. Nature 248, 136–137 (1974).
Lamden, M. P. & Chrystowski, G. A. Proc. Soc. exp. Biol. Mol. 85, 190–192 (1954).
Anderson, T. W. Ann. N.Y. Acad. Sci. 258, 498–503 (1975).
Ames, B. N., Lee, F. D. & Durston, W. E. Proc. natn. Acad. Sci. U.S.A. 70, 872–786 (1973).
Garro, A. J., Guttenplan, J. B. & Milvy, P. Mutat. Res. 38, 81–88 (1976).
Pauling, L. Proc. natn. Acad. Sci. U.S.A. 71, 4442–4446 (1976).
Altman, P. L. & Dittmer, D. S. Blood and Other Body Fluids 363–370 (Federation of American Societies for Experimental Biology, Washington DC, 1961).
Burch, H. B. Ann. N. Y. Acad. Sci. 92, 268–276 (1961).
McCann, J., Choi, E., Yamasaki, E. & Ames, B. N. Proc. natn. Acad. Sci. U.S. A 72, 5135–5139 (1975).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GUTTENPLAN, J. Inhibition by L-ascorbate of bacterial mutagenesis induced by two N-nitroso compounds. Nature 268, 368–370 (1977). https://doi.org/10.1038/268368a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/268368a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
