Abstract
LEDER and Leder1 have reported that low concentrations of n-butyrate cause Friend erythroleukaemia cells to begin globin synthesis. Apparently n-butyrate can reverse that part of viral transformation which prevents the expression of differentiation in these cells. Prasad and Sinha2 have summarised the effects of n-butyrate on neuroblastoma, HeLa, and other cell types. They and others3–10 have seen reversible inhibition of proliferation, decrease of DNA content, morphological modifications, and increases in the production of specific enzymes, such as adenylate cyclase, alkaline phosphatase, and a sialyltransferase. The present paper describes rapid, dramatic, and reversible increases in histone acetylation in the presence of n-butyrate.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Leder, A. & Leder, P. Cell 5, 319–322 (1975).
Prasad, K. N. & Sinha, P. K. In Vitro 12, 125–132 (1976).
Ginsburg, E., Salomon, D., Sreevalsan, T. & Freese, E. Proc. natn. Acad. Sci. U.S.A. 70, 2457–2461 (1973).
Wright, J. A. Expl Cell Res. 78, 456–460 (1973).
Griffin, M. J., Price, G. H., Bazzell, K. L., Cox, R. P. & Ghosh, N. K. Archs Biochem. Biophys. 164, 619–623 (1974).
Simmons, J. L., Fishman, P. H., Freese, E. & Brady, R. O. J. Cell Biol. 66, 414–424 (1975).
Ghosh, N. K., Deutsch, S. I., Griffin, M. J. & Cox, R. P. J. cell. Physiol. 86, 663–672 (1975).
Fishman, P. H., Bradley, R. M. & Henneberry, R. C. Archs Biochem. Biophys. 172, 618–626 (1976).
Altenburg, B. C., Via, D. P. & Steiner, S. M. Expl Cell Res. 102, 223–231 (1976).
Henneberry, R. C. & Fishman, P. H. Expl Cell Res. 103, 55–62 (1976).
Moss, B. A., Joyce, W. G. & Ingram, V. M. J. biol. Chem. 248, 1025–1031 (1973).
Alfageme, C. R., Zweidler, A., Mahowald, A. & Cohen, L. H. J. biol. Chem. 249, 3729–3736 (1974).
Ruiz-Carillo, A., Wangh, L. J. & Allfrey, V. G. Science 190, 117–128 (1975).
Gershey, E. L., Vidali, G. & Allfrey, V. G. J. biol. Chem. 243, 5018–5022 (1968).
Wong, T. K. & Marushige, K. Biochemistry 15, 2041–2046 (1976).
Thomas, G. & Hempel, K. Expl Cell Res. 100, 309–312 (1976).
Darzynkiewicz, Z., Traganos, F., Sharpless, T., Friend, C. & Melamed, M. R. Expl Cell Res. 99, 301–309 (1976).
Nudel, U. et al. Proc. natn. Acad. Sci. U.S.A. 74, 1100–1104 (1977).
Moore, M. R. & Chalkley, R. Fedn Proc. 36, 785 (1977).
Gusella, J., Geller, R., Clarke, B., Weeks, V. & Housman, D. Cell 9, 221–229 (1976).
Stanners, C. P., Eliceiri, G. L. & Green, H. Nature new Biol. 230, 52–54 (1971).
Panyim, S., Bilek, D. & Chalkley, R. J. biol. Chem. 246, 4206–4215 (1971).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
RIGGS, M., WHITTAKER, R., NEUMANN, J. et al. n-Butyrate causes histone modification in HeLa and Friend erythroleukaemia cells. Nature 268, 462–464 (1977). https://doi.org/10.1038/268462a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/268462a0
This article is cited by
-
Dysregulation of histone deacetylases in ocular diseases
Archives of Pharmacal Research (2024)
-
Modulation of bone remodeling by the gut microbiota: a new therapy for osteoporosis
Bone Research (2023)
-
Quantitative analysis of short-chain fatty acids in human plasma and serum by GC–MS
Analytical and Bioanalytical Chemistry (2022)
-
Bacterial epigenetics opens door to novel frontier in Infection biology
The Nucleus (2021)
-
The Antioxidants Glutathione, Ascorbic Acid and Uric Acid Maintain Butyrate Production by Human Gut Clostridia in The Presence of Oxygen In Vitro
Scientific Reports (2020)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
