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Autoimmune disease: why and where it occurs

Nature Medicine volume 7, pages 899–905 (2001)Cite this article

Abstract

Autoimmune disease is controlled by genetic and environmental factors. Both of these affect susceptibility to autoimmunity at three levels: the overall reactivity of the immune system, the specific antigen and its presentation, and the target issue.

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Figure 1
Figure 2: Chromosomal regions linked with autoimmune diseases.

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Acknowledgements

This work was supported by NIH grants AI-17134, AI-18785, AI-22295 and AR-37070.

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Authors and Affiliations

  1. Howard Hughes Medical Institute, University of Colorado Health Sciences Center, Denver, Colorado, USA

    Philippa Marrack & John Kappler

  2. Integrated Department of Immunology, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colorado, USA

    Philippa Marrack, John Kappler & Brian L. Kotzin

  3. Department of Biochemistry and Molecular Biology, University of Colorado Health Sciences Center, Denver, Colorado, USA

    Philippa Marrack

  4. Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado, USA

    John Kappler

  5. Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA

    Philippa Marrack, John Kappler & Brian L. Kotzin

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Marrack, P., Kappler, J. & Kotzin, B. Autoimmune disease: why and where it occurs. Nat Med 7, 899–905 (2001). https://doi.org/10.1038/90935

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