Research ArticleAtorvastatin inhibits proliferation and apoptosis, but induces senescence in hepatic myofibroblasts and thereby attenuates hepatic fibrosis in rats
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Keywords
cytokines
fibrogenesis
hepatic stellate cells
HMG-CoA reductase inhibitor
myofibroblasts
senescence
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Atorvastatin prevents liver fibrosis and is also a beneficial treatment for established fibrosis. The mechanisms are twofold: the prevention of hepatic stellate cell (HSC) activation, and decreased cytokine and collagen production in previously activated HSCs. Furthermore, atorvastatin decreases turnover and induces senescence of activated HSCs and hepatic myofibroblasts in injured livers.
© 2012 United States & Canadian Academy of Pathology.