Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter to the Editor
  • Published:

Sequencing histone-modifying enzymes identifies UTX mutations in acute lymphoblastic leukemia

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

References

  1. Claus R, Plass C, Armstrong SA, Bullinger L . DNA methylation profiling in acute myeloid leukemia: from recent technological advances to biological and clinical insights. Future Oncol 2010; 6: 1415–1431.

    Article  CAS  Google Scholar 

  2. Neff T, Armstrong SA . Chromatin maps, histone modifications and leukemia. Leukemia 2009; 23: 1243–1251.

    Article  CAS  Google Scholar 

  3. Slany RK . The molecular biology of mixed lineage leukemia. Haematologica 2009; 94: 984–993.

    Article  CAS  Google Scholar 

  4. Dalgliesh GL, Furge K, Greenman C, Chen L, Bignell G, Butler A et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 2010; 463: 360–363.

    Article  CAS  Google Scholar 

  5. van Haaften G, Dalgliesh GL, Davies H, Chen L, Bignell G, Greenman C et al. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet 2009; 41: 521–523.

    Article  CAS  Google Scholar 

  6. Ernst T, Chase AJ, Score J, Hidalgo-Curtis CE, Bryant C, Jones AV et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet 2010; 42: 722–726.

    Article  CAS  Google Scholar 

  7. Morin RD, Johnson NA, Severson TM, Mungall AJ, An J, Goya R et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet 2010; 42: 181–185.

    Article  CAS  Google Scholar 

  8. Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D et al. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature 2012; 481: 157–163.

    Article  CAS  Google Scholar 

  9. Parsons DW, Li M, Zhang X, Jones S, Leary RJ, Lin JC et al. The genetic landscape of the childhood cancer medulloblastoma. Science 2011; 331: 435–439.

    Article  CAS  Google Scholar 

  10. Chin L, Gray JW . Translating insights from the cancer genome into clinical practice. Nature 2008; 452: 553–563.

    Article  CAS  Google Scholar 

  11. Marston E, Weston V, Jesson J, Maina E, McConville C, Agathanggelou A et al. Stratification of pediatric ALL by in vitro cellular responses to DNA double-strand breaks provides insight into the molecular mechanisms underlying clinical response. Blood 2009; 113: 117–126.

    Article  CAS  Google Scholar 

  12. Metzeler KH, Hummel M, Bloomfield CD, Spiekermann K, Braess J, Sauerland MC et al. An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia. Blood 2008; 112: 4193–4201.

    Article  CAS  Google Scholar 

  13. Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P et al. A method and server for predicting damaging missense mutations. Nat Methods 2010; 7: 248–249.

    Article  CAS  Google Scholar 

  14. Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S et al. A histone H3 lysine 27 demethylase regulates animal posterior development. Nature 2007; 449: 689–694.

    Article  CAS  Google Scholar 

  15. Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P et al. The UTX gene escapes X inactivation in mice and humans. Hum Mol Genet 1998; 7: 737–742.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by NCI P01CA684841 and the Charles Hood Foundation. LB was supported in part by the Deutsche Forschungsgemeinschaft (Heisenberg-Stipendium BU 1339/3-1).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S A Armstrong.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mar, B., Bullinger, L., Basu, E. et al. Sequencing histone-modifying enzymes identifies UTX mutations in acute lymphoblastic leukemia. Leukemia 26, 1881–1883 (2012). https://doi.org/10.1038/leu.2012.56

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/leu.2012.56

This article is cited by

Search

Quick links