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Regulatory T cells protect the brain after stroke

The inflammatory response goes haywire after stroke, and the brain floods with immune mediators that can injure tissue and worsen outcome. Experiments in mice suggest that regulatory T cells help contain the damage (pages 192–199).

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Figure 1: Chronology of blood circulation and cerebral expression of cytokines, lymphocyte infiltration and brain infarct growth after mild to moderate brain ischemia.

Katie Vicari

References

  1. Chamorro, A. & Hallenbeck, J. Stroke 37, 291–293 (2006).

    Article  Google Scholar 

  2. Vila, N. et al. Stroke 34, 671–675 (2003).

    Article  CAS  Google Scholar 

  3. Prass, K. et al. J. Exp. Med. 198, 725–736 (2003).

    Article  CAS  Google Scholar 

  4. Chamorro, A., Urra, X. & Planas, A.M. Stroke 38, 1097–1103 (2007).

    Article  Google Scholar 

  5. Offner, H. et al. J. Immunol. 176, 6523–6531 (2006).

    Article  CAS  Google Scholar 

  6. Urra, X., Cervera, A., Villamor, N., Planas, A.M. & Chamorro, A. Neuroscience published online, doi:10.1016/j.neuroscience.2008.06.014 (13 June 2008).

    Google Scholar 

  7. Hallenbeck, J.M., Hansson, J.K. & Becker, K.J. Trends Immunol. 26, 550–556 (2005).

    Article  CAS  Google Scholar 

  8. Meisel, C. et al. Nat. Rev. Neurosci. 6, 775–786 (2005).

    Article  CAS  Google Scholar 

  9. Dromerick, A. & Reding, M. Stroke 25, 358–361 (1994).

    Article  CAS  Google Scholar 

  10. Elenkov, I.J., Wilder, R.L., Chrousos, G.P. & Vizi, E.S. Pharmacol. Rev. 52, 595–638 (2000).

    CAS  PubMed  Google Scholar 

  11. Liesz, A. et al. Nat. Med. 15, 192–199 (2009).

    Article  CAS  Google Scholar 

  12. Tang, Q. & Bluestone, J.A. Nat. Immunol. 9, 239–244 (2008).

    Article  CAS  Google Scholar 

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Planas, A., Chamorro, A. Regulatory T cells protect the brain after stroke. Nat Med 15, 138–139 (2009). https://doi.org/10.1038/nm0209-138

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