A recent study in a mouse model of colitis has demonstrated that interleukin (IL)-13, through inhibition of the mixed type 1 and type 17 T-helper cell inflammatory response, has a protective effect. The decoy receptor IL-13Rα2 inhibits this protective effect, suggesting blockade of IL-13Rα2 as a potential therapy for patients with IBD.
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Danese, S. Of mice and men—shedding new light on IL-13 activity in IBD. Nat Rev Gastroenterol Hepatol 8, 128–129 (2011). https://doi.org/10.1038/nrgastro.2011.17
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DOI: https://doi.org/10.1038/nrgastro.2011.17