Immunization against HBV has now been integrated into the WHO Expanded Programme on Immunization throughout the world. The reduction in chronic carriage rates in children from 10% to 0.9% over 25 years in Taiwan raises the exciting possibility that HBV could be targeted for eradication, but is vaccination alone sufficient to eliminate the infection?
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References
WHO. Hepatitis B. WHO [online], (2002).
Aggarwal, R., Ghoshal, U. C. & Naik, S. R. Assessment of cost-effectiveness of universal hepatitis B immunization in low-income country with intermediate endemicity using a Markov Model. J. Hepatol. 38, 215–222 (2003).
Ni, Y. H. et al. Minimization of hepatitis B infection by a 25-year universal vaccination program. J. Hepatol. http://dx.doi.org/10.1016/j.jhep.2012.05.021.
Ott, J. J., Stevens, G. A., Groeger, J. & Wiersma, S. T. Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity. Vaccine 30, 2212–2219 (2012).
Edmunds, W. J. et al. Epidemiological patterns of hepatitis B virus (HBV) in highly endemic areas. Epidemiol. Infect. 117, 313–325 (1996).
Chen, H. L. et al. Effects of maternal screening and universal immunization to prevent mother-to-infant transmission of HBV. Gastroenterology 142, 773–781 (2012).
van der Sande, M. A. et al. Long-term protection against HBV chronic carriage of Gambian adolescents vaccinated in infancy and immune response in HBV booster trial in adolescence. PLoS ONE 2, e753 (2007).
WHO. The Smallpox Eradication Programme. WHO [online], (2010).
Goldstein, S. T. et al. A mathematical model to estimate global hepatitis B disease burden and vaccination impact. Int. J. Epidemiol. 34, 1329–1339 (2005).
Thursz, M., Cooke, G. S. & Hall, A. J. Hepatitis B treatment in resource poor settings: time for action. Trop. Med. Int. Health 15, 2–4 (2010).
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Thursz, M., Njie, R. & Lemoine, M. Global eradication of hepatitis B—feasible or fallacy?. Nat Rev Gastroenterol Hepatol 9, 492–494 (2012). https://doi.org/10.1038/nrgastro.2012.155
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DOI: https://doi.org/10.1038/nrgastro.2012.155
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