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TRAPP complexes in membrane traffic: convergence through a common Rab

Nature Reviews Molecular Cell Biology volume 11, pages 759–763 (2010)Cite this article

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Abstract

Transport protein particle (TRAPP; also known as trafficking protein particle), a multimeric guanine nucleotide-exchange factor for the yeast GTPase Ypt1 and its mammalian homologue, RAB1, regulates multiple membrane trafficking pathways. TRAPP complexes exist in three forms, each of which activates Ypt1 or RAB1 through a common core of subunits and regulates complex localization through distinct subunits. Whereas TRAPPI and TRAPPII tether coated vesicles during endoplasmic reticulum to Golgi and intra-Golgi traffic, respectively, TRAPPIII has recently been shown to be reqiured for autophagy. These advances illustrate how the TRAPP complexes link Ypt1 and RAB1 activation to distinct membrane-tethering events.

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Figure 1: The TRAPP complex exists in three forms.
Figure 2: TRAPP complexes function in different membrane trafficking pathways.

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Acknowledgements

Salary support for J.B. is provided by US National Institutes of Health (NIH) grant R01 GM41223. Salary support for S.F.-N., and D.B. is provided by the Howard Hughes Medical Institute. Salary support for K.R. is provided by NIH grant R01 GM80616.

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Authors and Affiliations

  1. Jemima Barrowman is at the Department of Cell Biology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA.,

    Jemima Barrowman

  2. Deepali Bhandari and Susan Ferro-Novick are at the Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California at San Diego, La Jolla, California 92093-0668, USA.,

    Deepali Bhandari & Susan Ferro-Novick

  3. Karin Reinisch is at the Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.,

    Karin Reinisch

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Correspondence to Susan Ferro-Novick.

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Barrowman, J., Bhandari, D., Reinisch, K. et al. TRAPP complexes in membrane traffic: convergence through a common Rab. Nat Rev Mol Cell Biol 11, 759–763 (2010). https://doi.org/10.1038/nrm2999

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