Abstract
OBJECTIVE: Some studies have shown a more rapid gastric emptying in obese subjects. Six to twelve months after jejunoileal bypass (JIB) neurotensin (NT) and enteroglucagon have been shown to be elevated after food intake. These hormones, together with peptide YY (PYY) and glucagon-like peptide-1 (GLP-1) have been implicated in the reduction of upper gastrointestinal motility seen after infusion of nutrients into the ileum. AIM: To study if the postprandial gut hormone pattern and gastric emptying is altered 20 y after JIB. SUBJECTS: Seven subjects operated with JIB a mean (s.d.) 20±3 y ago, with a BMI of 44±4 kg/m2; at the time of surgery and 31±4 at present. For comparison seven sex-matched non-operated obese controls (BMI 43±3) were studied. METHODS: Serial blood samples were obtained every 10 min after intake of a 280 kcal meal. Radioimmunoassays for motilin, cholecystokinin (CCK), NT, PYY and GLP-1 were performed. Gastric emptying of a solid meal was studied using a radioactively labelled omelette (of 310 kcal) for 120 min). RESULTS: After JIB postprandial motilin, CCK, NT, PYY and GLP-1 were elevated compared to non-operated obese subjects. Similarly, basal levels of CCK, motilin, GLP-1 and PYY were elevated in the operated group. No difference was observed in the rate of gastric emptying between the two groups. CONCLUSION: Both fasting and postprandial gut hormone levels are elevated 20 y after JIB. The impact of long-term rapid stimulation of the ileum and subsequent raised gut hormone levels on gastric emptying is not clear.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Näslund, E., Grybäck, P., Hellström, P. et al. Gastrointestinal hormones and gastric emptying 20 years after jejunoileal bypass for massive obesity. Int J Obes 21, 387–392 (1997). https://doi.org/10.1038/sj.ijo.0800418
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/sj.ijo.0800418
Keywords
This article is cited by
-
Endobarrier® in Grade I Obese Patients with Long-Standing Type 2 Diabetes: Role of Gastrointestinal Hormones in Glucose Metabolism
Obesity Surgery (2017)
-
Role of gastrointestinal hormones in feeding behavior and obesity treatment
Journal of Gastroenterology (2016)
-
Relationship between gut hormones and glucose homeostasis after bariatric surgery
Diabetology & Metabolic Syndrome (2014)
-
Gastrointestinal hormones and polycystic ovary syndrome
Endocrine (2014)
-
Individually timing high-protein preloads has no effect on daily energy intake, peptide YY and glucagon-like peptide-1
European Journal of Clinical Nutrition (2011)