Abstract
Integration of the cell signaling circuitry determines the ultimate response of a cell to extracellular stimuli. The transcription factor nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase JNK1 are major players in the cell signaling circuitry, regulating numerous cellular events and being implicated in the process of many human diseases and certain types of cancer. The interplay between NF-κB and JNK1 provides a paradigm that shows how the crosstalk between different signaling pathways decides the function of the cell signaling circuitry. Understanding the wiring of the cell signaling circuitry may hold the key for cell signaling-based therapy of human diseases.
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This work is partially supported by grants from the National Institutes of Health. We apologize to the authors for not being able to directly cite their work due to the space constraints.
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Annning Lin would like to dedicate this review in memory of his father, Jun Lin, who passed away due to heart attack in Nanjing, China, on 28 November 2006.
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Liu, J., Lin, A. Wiring the cell signaling circuitry by the NF-κB and JNK1 crosstalk and its applications in human diseases. Oncogene 26, 3267–3278 (2007). https://doi.org/10.1038/sj.onc.1210417
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