Cytokines and acute pancreatitis
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Nanoparticle encapsulated CQ/TAM combination harmonizes with MSCs in arresting progression of severity in AP mice through iNOS (IDO) signaling
2022, Materials Today BioCitation Excerpt :BMSCs also down-regulated serum amylase and pancreatic cytokines at RNA level including TNF-α, IL-6 and IL-1β (Fig. 1C and D). Macrophages are believed to be the most likely source of proinflammatory agents (IL-1, IL-6, and TNF-α), and decrease of macrophage infiltration would consequently decrease cytokine levels [22]. As these cytokines will increase capillary permeability and promote leukocyte adherence and extravasation [22], BMSCs decreased the pathological scores including edema and inflammation probably by lowering the cytokine level.
Protective effects of Coenzyme Q10 against acute pancreatitis
2020, International ImmunopharmacologyRedox signaling in acute pancreatitis
2015, Redox BiologyCitation Excerpt :Clinically, SAP occurs in two stages. In the first phase, a systemic inflammatory response syndrome might arise leading to multiple organ failure within the first few days [8,9]. If this process is not restrained or stopped, the second phase will appear, developing local complications and a subsequent compensatory anti-inflammatory response syndrome (CARS).
Guggulsterone attenuates cerulein-induced acute pancreatitis via inhibition of ERK and JNK activation
2015, International ImmunopharmacologyCitation Excerpt :Therefore, the levels of these pro-inflammatory cytokines were evaluated in AP. TNF-α, IL-1β, and IL-6 can be detected 1 h after induction of AP, with the levels of these cytokines rapidly increasing over the next 6 h [12,45]. In our experimental model of AP, levels of TNF-α, IL-1β, and IL-6 in serum and pancreas were elevated during AP.