Pathogenesis of gastric metaplasia of the human duodenum: Role of Helicobacter pylori, gastric acid, and ulceration
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Histologic heterogeneity and syndromic associations of non-ampullary duodenal polyps and superficial mucosal lesions
2021, Digestive and Liver DiseaseCitation Excerpt :We found fewer cases of Brunner's gland proliferative lesions and no case of hyperplastic polyp, which is a very uncommon duodenal lesion, contrasting the high frequency in the large bowel [21]. Foveolar metaplasia is a common finding in duodenal biopsy specimens, especially in the duodenal bulb, as a reactive process after ulcers or chronic inflammatory diseases [22]. Two cases of foveolar metaplasia in our series were classified as “atypical foveolar metaplasia”, a concept that is still debated.
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2009, The LancetCitation Excerpt :Resolution of hypergastrinaemia in these patients after H pylori eradication is a common event and occurs much faster than does resolution of acid hypersecretion.35,43,44 Gastric acid hypersecretion and, more specifically, acid overload in the duodenum leads to development of metaplasia in the duodenal bulb.45 Metaplasia is a prerequisite for H pylori colonisation of duodenal epithelium, because colonisation is specific and exclusive to gastric epithelial cells.