Clonal analysis of precancerous lesion of hepatocellular carcinoma
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Scheuer’s Liver Biopsy Interpretation
2015, Scheuer's Liver Biopsy InterpretationSequential transcriptome analysis of human liver cancer indicates late stage acquisition of malignant traits
2014, Journal of HepatologyCitation Excerpt :Depending on the degree of dysplasia, they are divided into low (LGDN) and high grade (HGDN). However, diagnosis of pre-malignant lesions and discrimination from eHCC is often difficult, and, although dysplastic nodules are considered monoclonal in origin, a clear probability of malignant transformation could not be attributed to a specific pre-neoplastic lesion [3]. According to current clinical guidelines, advanced HCCs are diagnosed with the use of a single dynamic imaging technique with biopsies being optional and most often reserved for ambiguous cases [4].
SUOX is a promising diagnostic and prognostic biomarker for hepatocellular carcinoma
2013, Journal of HepatologyCitation Excerpt :HCC occurs mainly in patients with chronic liver diseases such as hepatitis B virus (HBV) or hepatitis C virus infection-based liver cirrhosis. Dysplastic nodules (DNs) are precancerous lesions of HCC and high-grade DNs (HGDNs) have a high risk of malignant transformation [2–5]. However, detection of DNs, especially HGDNs, and correct differentiation from well-differentiated small HCC (WD-sHCC), are sometimes difficult on the basis of clinical, imaging, and even morphological examination.
Induction of p53 Renders ATM-Deficient Mice Refractory to Hepatocarcinogenesis
2010, GastroenterologyLiver
2009, Modern Surgical PathologyLiver
2009, Modern Surgical Pathology