Clinical characteristics of Crohn's disease in 72 families
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Cited by (177)
Inflammatory Bowel Disease: What Very Early Onset Disease Teaches Us
2018, Gastroenterology Clinics of North AmericaUncovering Pathogenic Mechanisms of Inflammatory Bowel Disease Using Mouse Models of Crohn's Disease–Like Ileitis: What is the Right Model?
2017, Cellular and Molecular Gastroenterology and HepatologyGenetics and phenotypes in inflammatory bowel disease
2016, The LancetPhenotypic concordance in familial inflammatory bowel disease (IBD). Results of a nationwide IBD Spanish database
2014, Journal of Crohn's and ColitisCitation Excerpt :Phenotypic concordance in familial IBD has been reported to be higher in CD than UC families. Several studies have reported a high degree of agreement for both location and clinical disease behaviour in pairs of relatives with CD, with concordance indices ranging from 46% to 83%, and 49% to 73%, respectively18,19,22,23. In agreement with other studies,13,17,20 however, we were unable to find relevant concordance for these phenotypic features as well as for the presence of perianal disease and extraintestinal manifestations in CD pairs.
Disease severity in familial cases of IBD
2014, Journal of Crohn's and ColitisCitation Excerpt :Previous analyses on the phenotypic differences between familial and sporadic IBD are controversial. Whereas some studies did not show phenotypic differences,4,7,8 others found that in familial cases, disease onset occurs at an earlier age and suffers from a higher disease extent than in sporadic cases.9,10 Provision of robust data on this aspect might prove of value in our goal to offer our patients a personalized health care.