Gallbladder emptying and gallstone formation: A prospective study on gallstone recurrence
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Discovery and exploration of novel somatostatin receptor subtype 5 (SSTR5) antagonists for the treatment of cholesterol gallstones
2024, European Journal of Medicinal ChemistryAn Update on Biliary Dyskinesia
2019, Surgical Clinics of North AmericaCitation Excerpt :The clinical relevance of this finding is unclear. Generally, a gallbladder ejection fraction of greater than 60% indicates normal gallbladder function and can support nonoperative management in patients with cholelithiasis.42,43 Regardless, primary care providers and some gastroenterologists have interpreted a high gallbladder ejection fraction as abnormal.
EASL Recognition Award Recipient 2017: Prof. Gustav Paumgartner
2017, Journal of HepatologyTargets for current pharmacologic therapy in cholesterol gallstone disease
2010, Gastroenterology Clinics of North AmericaPathogenesis of gallstones
2010, Gastroenterology Clinics of North AmericaCitation Excerpt :Patients with good postprandial contraction often have increased fasting and residual gallbladder volumes compared with normal controls.32 Prospective studies also indicate that impaired postprandial gallbladder motility is an independent risk factor for gallstone recurrence after successful treatment with extracorporeal shockwave lithotripsy.33 It is less well appreciated that significant periodic gallbladder emptying also occurs during the fasting state (20%–30% emptying in the fasting state vs 70%–80% emptying after a meal) at 1- to 2-hour intervals, associated with the cycle of the intestinal migrating motor complex and with a rise of plasma motilin levels.34
Mandatory and optional function tests for biliary disorders
2009, Best Practice and Research: Clinical GastroenterologyCitation Excerpt :Gallbladder function was determined before and after dissolution therapy. The risk for gallstone recurrence was approximately four-fold higher in patients with a gallbladder ejection fraction of <60% (53 vs. 13% three years after dissolution therapy) [35]. Another trial including 54 patients who also underwent ESWL plus UDCA for the dissolution of gallstones showed that stone recurrence was postponed in patients with postprandial residual gallbladder volume <6 ml (recurrence rate 21 vs. 53% two years after treatment) [36].