Human stomach alcohol and aldehyde dehydrogenases: Comparison of expression pattern and activities in alimentary tract
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Alcoholic liver disease
2020, Influence of Nutrients, Bioactive Compounds, and Plant Extracts in Liver DiseasesMetabolic Barrier of the Gastrointestinal Tract
2018, Comprehensive Toxicology: Third EditionKey role of local acetaldehyde in upper GI tract carcinogenesis
2017, Best Practice and Research: Clinical GastroenterologyCitation Excerpt :Stomach mucosa possesses ADH activity representing 1/3rd of that in the esophagus and 1/12th of that in the liver [100,101]. In contrast to oropharynx, gastric mucosa contains also ALDH enzymes with 2.2 times higher activity than in the oesophagus and 1/8th of that in the liver [100,101]. Furthermore, gastric mucosa expresses some cytochrome P4502E1 activity [102].
In vitro activity and stability of pure human salivary aldehyde dehydrogenase
2017, International Journal of Biological MacromoleculesCitation Excerpt :This isozyme (ALDH3) has also been found to be involved in the chemoresistance of certain types of cancers as it catalyzes the oxidation of the chemotherapeutic drugs such as oxazaphosphorine and cyclophosphamide [11,24–29]. ALDH3A1 is also expressed in other organs and tissues such as the stomach, hair roots, cornea, liver and lungs [6,7,30–32]. Apart from detoxification, ALDH3A1 is involved in other physiological functions such as cell proliferation, protection from UV radiation and oxidative damage in the cornea, etc. [31,33].
Ethanol oxidation and the inhibition by drugs in human liver, stomach and small intestine: Quantitative assessment with numerical organ modeling of alcohol dehydrogenase isozymes
2016, Chemico-Biological InteractionsCitation Excerpt :All patients provided written informed consent and the studies were approved by the Institutional Review Board of the National Defense Medical Center [10–12]. It is also noted that sex and age did not significantly influence hepatic and gastrointestinal mucosal ADH activities with specified genetic phenotypes [10–12]. The ratio of the total subunit contents of class I ADH1A, ADH1B and ADH1C in liver was estimated from CM-cellulose chromatography of the isolated mixture of class I isozymes [26].