The role of endothelial nitric oxide synthase in the pathogenesis of a rat model of hepatopulmonary syndrome
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Hepatopulmonary syndrome
2022, JHEP ReportsCitation Excerpt :The underlying processes responsible for these 3 mechanisms are described in more detail below and are summarised in Fig. 3. Circulating endothelin-1 (ET-1) levels and hepatic production are increased in both human and experimental cirrhosis.21,22,24 ET-1 classically acts as a potent vasoconstrictor, including in the portal circulation where it increases sinusoidal and pre-sinusoidal resistance.
Hepatopulmonary Syndrome
2021, Encyclopedia of Respiratory Medicine, Second EditionTransjugular Intrahepatic Portosystemic Shunts: Advances and New Uses in Patients with Chronic Liver Disease
2020, Clinics in Liver DiseasePulmonary Complications of Portal Hypertension
2019, Clinics in Liver DiseaseCitation Excerpt :HPS has also been diagnosed in patients with presinusoidal portal hypertension with otherwise normal liver function. A rat common bile duct ligation model of HPS has immensely helped in the understanding of this syndrome.117,118 In this model, proliferating cholangiocytes in the liver produce and secrete ET-1.117,118
EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis
2018, Journal of Hepatology
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