Familial aggregation of gastroesophageal reflux in patients with Barrett's esophagus and esophageal adenocarcinoma
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The Evolving Genomic Landscape of Barrett's Esophagus and Esophageal Adenocarcinoma
2017, GastroenterologyCitation Excerpt :A portion of the heritability of EA and BE may be explained by germline variants that affect development and severity of risk factors for these conditions, including symptomatic GER and obesity.30–33 For example, a study based on self-administered questionnaires found that GER symptoms were substantially more prevalent among first-degree relatives of persons with BE or EA than among first-degree relatives of their spouses.34 Twin studies of symptomatic GER support the concept of an important susceptibility component, with heritability estimates ranging from 13% to 41%.35–37
Genetic Insights in Barrett's Esophagus and Esophageal Adenocarcinoma
2015, GastroenterologyHiatus hernia and gastro-oesophageal reflux disease
2015, Medicine (United Kingdom)Citation Excerpt :It is important to remember that one can have a hiatus hernia with no symptoms of GORD and vice versa. Risk factors for GORD include genetic predisposition (up to 30% of the risk),5 abdominal obesity, pregnancy, hiatus hernia, delayed gastric emptying and age. Less common factors include medications, such as calcium channel blockers, anticholinergics and nitrates, which reduce lower oesophageal sphincter (LOS) pressure.
Barrett's oesophagus: Can meaningful screening and surveillance guidelines be formulated based on new data and rejigging the old paradigm?
2015, Best Practice and Research: Clinical GastroenterologyObesity
2015, Williams Textbook of EndocrinologyFamilial Clustering of Barrett's Esophagus and Esophageal Adenocarcinoma in a European Cohort
2014, Clinical Gastroenterology and Hepatology