Alimentary TractAtrophy and intestinal metaplasia one year after cure of H. pylori infection: A prospective, randomized study☆,☆☆
Section snippets
Patients and methods
The study was a collaborative study between the Chinese University of Hong Kong and the Beijing Medical University, approved by the Medical Ethics Committee of the Chinese University of Hong Kong. An endoscopic study was conducted in 11 rural villages around the county of Yantai in the Shangdong province. The location was chosen for the study for 2 reasons: Yantai is known to have a high incidence of gastric cancer (50 per 100,000 population), and rapport has been established between the local
Results
A total of 1024 subjects were screened in this study. Four subjects were considered unfit for examination because of comorbid medical conditions, and 2 subjects refused endoscopy. Endoscopic examination revealed 4 cases of gastric cancer, 1 case of esophageal cancer, and 25 cases with previous gastrectomy. These patients were excluded from randomization. In the remaining 988 subjects, 600 cases with a positive RUT result were randomized. In 13 RUT-positive subjects, H. pylori infection could
Discussion
H. pylori is one of the causative factors of gastric cancer. Its eradication may have an important role in the prevention of gastric cancer. The effect of H. pylori eradication on premalignant lesions of the stomach has intrigued many investigators worldwide. However, conflicting messages have been reported in previous studies. Genta et al.4 reported a minor decrease in the average grade of IM in 11 patients in the corpus 1 year after therapy. Haruma et al.5 followed up 20 patients for 6 months
Acknowledgements
The authors thank Ashley Lymee Yu for advice in statistical analysis and Olympus China for technical support.
References (20)
- et al.
Effect of Helicobacter pylori eradication on gastritis in relation to cagA: a prospective 1-year follow-up study
Gastroenterology
(1997) - et al.
Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer
Gastroenterology
(1998) - et al.
Modelling cost-effectiveness of Helicobacter pylori screening to prevent gastric cancer: a mandate for clinical trial
Lancet
(1996) - et al.
Helicobacter pylori infection and gastric cancer
J Pathol
(1996) - et al.
Epidemiology of H. pylori in southern China: identification of early childhood as the critical period for acquisition
J Infect Dis
(1992) Helicobacter pylori and gastric carcinogenesis
Am J Surg Pathol
(1995)- et al.
Changes in the gastric mucosa following eradication of H. pylori
Mod Pathol
(1993) - et al.
Eradication of Helicobacter pylori reverses intestinal metaplasia in patients with severe atrophic gastritis (abstr)
Gastroenterology
(1997) - et al.
Do intestinal metaplasia and glandular atrophy reverse after H. pylori eradication?
Gut
(1997) - et al.
Lack of reversibility of epithelial proliferative changes after H. pylori eradication in areas of intestinal metaplasia (abstr)
Gut
(1996)
Cited by (335)
The influence of the gastric microbiota in gastric cancer development
2021, Best Practice and Research: Clinical GastroenterologyEgyptian recommendations for management of Helicobacter pylori infection: 2018 report
2019, Arab Journal of Gastroenterology
- ☆
Address requests for reprints to: Joseph J. Y. Sung, M.D., Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong, China. e-mail: [email protected]; fax: (852) 2646-7824.
- ☆☆
Supported by an unrestricted grant from the Hong Kong Society of Digestive Endoscopy.