EditorialsA case for an immunological basis for irritable bowel syndrome☆
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Acknowledgements
The author is a consultant for Astra Zeneca, Solvay, and Glaxo Smith Kline.
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Cited by (69)
Probiotics in the Management of Functional Bowel Disorders. Promise Fulfilled?
2012, Gastroenterology Clinics of North AmericaCitation Excerpt :Furthermore, several risk factors for the development of PI-IBS have been identified.15,17 Although results have not always been consistent,18–20 others have described low-grade mucosal inflammation and immune activation in IBS in general21–32 as well as evidence of microbe-host engagement.33,34 The enteric flora has also been implicated in the pathogenesis of non–PI-IBS.35
Gut memories: Towards a cognitive neurobiology of irritable bowel syndrome
2012, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Furthermore, the review of the literature above indicates that further investigation is clearly warranted to elucidate the relationship between alterations in the stress response and its impact on cognitive functioning in IBS. There is ever increasing evidence to support a role for immune activation in IBS (Clarke et al., 2010; Collins, 2002). A number of patients report the onset of symptoms following an episode of acute gastroenteritis (Spiller et al., 2000), and a number of studies have documented and confirmed bacterial gastroenteritis prior to the onset of IBS (Cumberland et al., 2003; Dunlop et al., 2003; Neal et al., 1997; Spiller et al., 2000).
Do interactions between stress and immune responses lead to symptom exacerbations in irritable bowel syndrome?
2011, Brain, Behavior, and ImmunityCitation Excerpt :Thus, stress is a known pre-disposing factor for mood disorders (Cryan and Holmes, 2005) and also independently contributes to the persistence and severity of gastrointestinal symptoms in IBS (Blanchard et al., 2007; Mayer et al., 2001; O’Mahony et al., 2009; Saito and Talley, 2009). When taken in the context of the emerging hypothesis that low-grade inflammation or immune activation are central to the pathophysiology of IBS symptoms (Collins, 2002), the potential for crosstalk between the immune and stress axes becomes apparent. Familial clustering and twin studies indicate the possibility of genetic factors being a contributory component in the susceptibility of developing IBS (Bengtson et al., 2006; Levy et al., 2001; Morris-Yates et al., 1998).
Irritable bowel syndrome and inflammatory bowel disease: Is there a connection?
2009, Gastroenterologia y HepatologiaSystematic review of modulators of benzodiazepine receptors in irritable bowel syndrome: Is there hope?
2011, World Journal of GastroenterologyThe role of Weizmannia (Bacillus) coagulans LMG S-31876 in treating IBS-diarrhea
2023, Frontiers in Nutrition
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Address requests for reprints to: Stephen M. Collins, MBBS, FRCP (UK), FRSCP, Division of Gastroenterology, McMaster University Medical Center, Room 4W8, 1200 Main Street West, Hamilton, Ontario L8N 3Z5 Canada. e-mail: [email protected]; fax: (905) 521-4958.