Clinical–Alimentary TractLong-term improvement in functional dyspepsia using hypnotherapy☆,☆☆
Section snippets
Patients
All patients attending the endoscopy unit at the University Hospital of South Manchester with dyspeptic symptoms and a negative endoscopy were considered for the study, and those fulfilling the Rome I19 criteria for FD were recruited. Patients were excluded if they had predominant gastroesophageal reflux-like symptoms, had a history of peptic ulcer disease, or were regularly using nonsteroidal anti-inflammatory drugs. All patients with a history of abdominal surgery, with the exception of
Results
Recruitment of patients and their flow through each stage of the study, as recommended by the CONSORT statement,28 are illustrated in Figure 2.A total of 149 patients were eligible for the study, of which 23 (15%) declined to participate, leaving 126 patients. Of these 126 patients, 32 were randomized to receive HT; 48, to supportive therapy; and 46, to medical
Discussion
This study clearly demonstrates that HT is more effective than medical treatment or supportive therapy plus placebo medication in both the short- and long-term management of FD. HT not only improves all aspects of symptomatology and QOL, but also has considerable economic advantages. Of particular interest is the striking difference in the medication needs of the 3 groups. None of the patients receiving HT resumed any form of drug therapy, whereas 90% of patients in the medical group and 82% of
Acknowledgements
The authors thank Professor M. J. S. Langman for helpful criticism during the preparation of this manuscript.
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Address requests for reprints to: Peter J. Whorwell, M.D., Department of Medicine, Education and Research Centre, Wythenshawe Hospital, Southmoor Road, Manchester M23 9LT, United Kingdom. e-mail: [email protected]; fax: (44) 161-434-5194.
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Supported by a grant from the Wellcome Trust.