Clinical–Liver, Pancreas, and Biliary TractAssociations of chemokine system polymorphisms with clinical outcomes and treatment responses of chronic hepatitis C
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Beyond HIV infection: Neglected and varied impacts of CCR5 and CCR5Δ32 on viral diseases
2020, Virus ResearchCitation Excerpt :Due to those and other reasons, the results of Woitas et al. (2002) were criticized by different authors (Klein, 2003; Mangia et al., 2003; Poljak et al., 2003; Promrat et al., 2003; Zhang et al., 2003). In this sense, no influence of CCR5Δ32 on susceptibility to HCV infection were reported in studies performed with various populations (Glas et al., 2003; Mangia et al., 2003; Poljak et al., 2003; Promrat et al., 2003; Zhang et al., 2003; Ruiz-Ferrer et al., 2004; Wald et al., 2004; Wasmuth et al., 2004; Thoelen et al., 2005; Goyal et al., 2006). Reinforcing the observations of those different studies, our group found no association between the CCR5Δ32 and susceptibility to HCV infection or HCV/HIV co-infection in a study that evaluated a large number of Brazilian individuals (Ellwanger et al., 2018b).
CCR5Δ32 in HCV infection, HCV/HIV co-infection, and HCV-related diseases
2018, Infection, Genetics and EvolutionCitation Excerpt :In line with the criticisms made regarding this study conclusions, our results do not support an influence of the CCR5Δ32 allele on the susceptibility to HCV infection or HCV/HIV co-infection in the Brazilian population. Our findings are in agreement with several other studies evaluating different populations (Glas et al., 2003; Goyal et al., 2006; Promrat et al., 2003; Thoelen et al., 2005; Wald et al., 2004; Wasmuth et al., 2004). Moreover, previous studies of our group indicate that the ethnic background impacts the susceptibility to infectious and autoimmune diseases in the Brazilian population (Glesse et al., 2017; Schauren et al., 2013; Valverde-Villegas et al., 2017).
Stem cell-based therapies for HIV/AIDS
2016, Advanced Drug Delivery ReviewsGenomics and HCV infection: Progression of fibrosis and treatment response
2012, Journal of HepatologyCitation Excerpt :Interestingly, a common 32-base deletion in the CCR5 gene has been associated with resistance to HIV-1 infection [86–88]. The potential role of CCR5 deletion in resistance to HCV has been studied and suggested to adversely affect outcome of HCV infection [89–94]. However, the different reports are conflicting.
Single nucleotide polymorphisms and risk of hepatocellular carcinoma in cirrhosis
2012, Journal of Hepatology