Clinical-alimentary tractAssociation of antibody responses to microbial antigens and complications of small bowel Crohn’s disease☆
Section snippets
Patients
The cohort of 303 patients was ascertained from patients assessed at the Cedars-Sinai Medical Center from 1993 to 2002. All research-related activities were approved by the Cedars-Sinai Medical Center Institutional Review Board. The diagnosis of CD was based on standard endoscopic, histological, and radiographic features. At least 2 of the following characteristics were required for diagnosis: (1) clinical—perforating or fistulizing disease and obstructive symptoms secondary to stenosis or
Clinical, serological, and genetic characteristics of the study population
The relationship of individual antibody responses toward microbial antigens and autoantigens and disease phenotype has been reported previously. These prior studies indicate that in CD, a proportion of patients have serum reactivity against oligomannans (ASCA; 40%–60%),18, 35, 36 toward I2 (54%),17 and toward OmpC (56%)17 and exhibit pANCA (10%–40%).19 The first task was to determine the serum reactivity to each of these antigens in our cohort of CD patients. Figure 1 shows the scatter graph
Discussion
The pathogenesis of CD involves the aberrant recognition of luminal microbial antigens. In this study, we examined the relationship between humoral responses to microbial antigens and clinical manifestations in CD. Patients with CD can be grouped by their antibody responses toward individual microbial antigens and autoantigens, as evidenced by antibody responses toward I2 and OmpC and the expression of ASCA and pANCA.17 We hypothesized that in genetically predisposed hosts, these antibody
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Cited by (0)
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Supported by National Institutes of Health/Public Health Service grants PO1-DK46763 and RO1-DK54967, National Institutes of Health GI Training grant T32 DK07180-27, the Cedars-Sinai Board of Governors Chair in Medical Genetics, the Feintech Family Chair in Inflammatory Bowel Disease, and the Eli and Edythe Broad Medical Research Foundation.
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Drs. Targan and Landers have an equity interest in Prometheus Laboratories. Dr. Abreu-Martin is a consultant for Prometheus Laboratories.