Clinical-liver, pancreas, and biliary tractClinical relevance of hepatitis B virus genotype in children with chronic infection and hepatocellular carcinoma
Section snippets
Materials and methods
Under parental written consent, 460 HBsAg carrier children were followed-up consecutively every 6 months. These carrier children were enrolled from (1) the outpatient clinic of the National Taiwan University Hospital in a prospective study beginning approximately 23 years ago,18 (2) a prospective screening program for carrier children of HBsAg-seropositive mothers, and (3) 4 cross-sectional studies regarding a hepatitis B vaccination efficacy survey in 1984, 1989, 1994, and 1999.19 Each child
Basic and biochemical data
The baseline and peak ALT levels of the 3 groups of chronic HBV-infected children and the HCC group are shown in Table 1. Their ages at enrollment and at diagnosis were statistically different, the children in the HCC group were older than those in the HBV-infected groups (Mann–Whitney rank test, P < .001). At the latest follow-up evaluation, the ages of the 3 HBV carrier groups were approximately the same (P > .5).
Genotype distribution
Genotype B is the predominant strain of HBV in these children, but the
Discussion
This childhood study supplements the lack of data regarding HBV genotype during the natural history of chronic HBV infection in the first 2 decades of life. Our results confirmed previous observations in adults that HBV genotype B is most common in Taiwan.25 In the meantime, we confirmed that genotype C rather than genotype B delays HBeAg seroconversion in carrier children by 2 approaches: first, genotype C constituted a larger proportion in the HBeAg(+/+) than the other groups; and second,
References (31)
- et al.
Precore stop codon mutant in chronic hepatitis B virus infection in childrenits relation to hepatitis B seroconversion and maternal hepatitis B surface antigen
J Hepatol
(1998) - et al.
Long-term follow-up study of core gene deletion mutants in children with chronic hepatitis B virus infection
Hepatology
(2000) - et al.
Significance of hepatitis B genotype in acute exacerbation, HBeAg seroconversion, cirrhosis-related complications, and hepatocellular carcinoma
Hepatology
(2003) - et al.
Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease
Hepatology
(2003) - et al.
Hepatitis B genotypes and the response to interferon therapy
J Hepatol
(2000) - et al.
Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B
Gastroenterology
(2000) - et al.
Significance of hepatitis B genotype in acute exacerbation, HBeAg seroconversion, cirrhosis-related complications, and hepatocellular carcinoma
Hepatology
(2003) - et al.
Hepatitis B virus genotype B is associated with earlier HBeAg seroconversion compared with hepatitis B virus genotype C
Gastroenterology
(2002) - et al.
Acute exacerbations of chronic hepatitis B are rarely associated with superinfection of hepatitis B virus
Hepatology
(2001) - et al.
The significance of spontaneous hepatitis B e antigen seroconversion in childhoodwith special emphasis on the clearance of hepatitis B e antigen before 3 years of age
Hepatology
(1995)
Combined real time PCR quantification and signature single nucleotide polymorphism genotyping of hepatitis B virus in one-tube reaction
J Hepatol
Chronic hepatitis virus infection in children
J Gastroenterol Hepatol
Typing hepatitis B virus by homology in nucleotide sequencecomparison of surface antigen subtypes
J Gen Virol
A new genotype of hepatitis B viruscomplete genome and phylogenetic relatedness
J Gen Virol
Genotype Ha new Amerindian genotype of hepatitis B virus revealed in Central America
J Gen Virol
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Supported by grants from the National Science Council, Executive Yuan, Taiwan (NSC-90-2314-B-002-154 and NSC-91-2314-B-002-149).