Basic–alimentary tractCandida albicans Is an Immunogen for Anti–Saccharomyces cerevisiae Antibody Markers of Crohn’s Disease
Section snippets
Patients
Twenty-seven patients with CD (16 females, 11 males; 26–88 years of age), 17 patients with proven systemic candidiasis (7 females, 10 males; 1–79 years of age), 25 patients with UC (12 females, 13 males; 27–76 years of age), and 10 healthy controls (5 females, 5 males; 19–40 years of age) were included in the study. Sera from all subjects were collected from the Clinical Mycology Laboratory of the University Hospital of Lille. Diagnosis of CD or UC was based on clinical, endoscopic, and
Bioclinical Evidence for a Relationship Between Generation of ASCA and Anti–C albicans Antibodies in Patients With CD and Candidiasis
Although ASCAs are usually stable serologic markers of CD, it was possible to select 3 patients from our diagnostic serum bank who presented ASCA seroconversion (from negative to positive) during their serologic monitoring. The clinical characteristics of these patients are summarized in Table 2. Sequential analysis of ASCA titers in these 3 CD patients is shown in Figure 1A. During the follow-up period of between 400 and 1000 days, ASCA titers against S cerevisiae PPM became significant for CD
Discussion
The main result of this study is that C albicans was found to express the major ASCA epitopes on several cell wall molecules. Overexpression of ASCA epitopes by C albicans was shown to be triggered by growth conditions. Among these, the pathogenic phase of C albicans was shown to be a strong immunogen for ASCA.
Initial clinical studies performed by using different yeast species and strains revealed the presence of antibodies to both C albicans and S cerevisiae in sera from patients with
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