Clinical–alimentary tractGastric Sensorimotor Functions and Hormone Profile in Normal Weight, Overweight, and Obese People
Section snippets
Participants
Seventy-three healthy volunteers of normal weight (body mass index [BMI], 18–24.9 kg/m2), overweight (BMI, 25–29.9 kg/m2), and obese (BMI, >30 kg/m2) categories were recruited. They were contacted either by letter from a database of residents from Olmsted County, Minnesota who previously had replied to a questionnaire mailing or by public advertisement.
Men and women between the ages of 18 and 65 years residing in Olmsted County, Minnesota who were not currently on treatment for cardiac,
Participant Demographics
Seventy-three subjects were recruited from January 2005 to December 2005. One subject in the normal weight group had a vasovagal reaction to needles and could not complete the study and is not included in the analyses. None of the participants had features suggestive of bulimia. Table 1 summarizes the baseline characteristics (mean ± SEM) for the normal, overweight, and obese participants. No associations with age, sex, and race with BMI group status were detected.
Anthropometrics
As expected from the design of
Discussion
Our study addressed 2 aims: first, to compare gastric motor and sensory functions and hormonal responses in 3 BMI groups ranging from normal weight to obesity; and second, to evaluate the relationship between these gastric and hormonal factors in response to feeding across a broad range of body mass.
First, this study has shown that there were similar rates of gastric emptying of solids, MTV, and postchallenge symptoms in the 3 body mass groups corresponding to normal weight, overweight, and
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Supported by General Clinical Research Center grant (M01-RR00585; patient care, gastrointestinal, and immunochemistry cores) from the National Institutes of Health and by grants R01 DK67071 and K24 DK02638 to Dr Camilleri from the National Institutes of Health.