Clinical–Alimentary TractEosinophilic Esophagitis: A Prevalent Disease in the United States That Affects All Age Groups
Section snippets
Study Design and Database
This study identified patients diagnosed with EE using the Caris Diagnostics Database (based in Irving, TX). This database is derived from all patients referred to Caris Diagnostics, a provider of gastrointestinal pathology services for physicians from community-based freestanding endoscopy centers throughout the United States. Over the study period, the database contained 414,598 patient gastrointestinal pathology cases from 34 different states. This is a predominantly adult database, with
Results
During the study period, esophageal and/or gastroesophageal biopsy specimens were obtained from upper endoscopies in 74,162 unique patients. In this cohort of patients, roughly 98% were adults, and 2% were younger than 18 years. The cohort represented 217 different clients (≥1 physician at each client endoscopy center) in 34 different states for adult cases, and 74 clients in 23 states for pediatric cases. Over the 5-year study period, the age and sex were very similar year to year, with the
Discussion
This study examined a large population of patients with EE derived from a national database. There are several strengths of this study, most notable is that it is one of the largest series of patients with EE to date. Because cases were derived from samples submitted by community practices in 34 of the 50 states it is both geographically diverse and less prone to referral center bias. Cases were nested within the larger cohort of all patients who had undergone an upper endoscopy with biopsy
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Dr. Kapel is a consultant to Caris Diagnostics.
R.C.K. and J.K.M. are both first authors.