Comment from the EditorWithin You, Without You: Is Gastroenterology Ready to Embrace the “Exposome”?
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Cited by (8)
Environmental Risk Factors for Inflammatory Bowel Diseases: An Umbrella Review of Meta-analyses
2019, GastroenterologyCitation Excerpt :Data from more studies and investigation of sources of heterogeneity are warranted to better understand the role of the remaining factors and IBD, especially those assessed in meta-analyses including few studies and disease cases or showing unexplained heterogeneity and multiple biases. Regarding future research, high-quality prospective studies should be complemented by an analysis of the exposome (eg, exploring exposures through the analysis of the internal milieu of an individual as reflected in the blood or tooth matrix109 using “-omics” technologies) of patients with new-onset IBD to ascertain the causality of these associations and clarify the underlying mechanisms.110 As other researchers have pointed out, more widespread use of standardized definitions for outcomes and exposures,111 the adoption of the Strengthening the Reporting of Observational Studies in Epidemiology (ie, STROBE) reporting guidelines,112 and registration of hypothesis-testing observational studies113 may help improve the evidence.
Understanding and Preventing the Global Increase of Inflammatory Bowel Disease
2017, GastroenterologyAir pollution exposure: A novel environmental risk factor for interstitial lung disease?
2015, ChestCitation Excerpt :The concept of the exposome was initially proposed as a framework to complement the genome, accounting for an individual's nongenetic/environmental risk factors for malignancy.49 It has since been refined and applied more broadly to environmental epidemiology and exposure assessment in the context of other disease processes, including type 2 diabetes, inflammatory bowel disease, and addiction.50–54 The exposome characterizes all cellular processes in a framework where the “environment” can be conceptualized as the individual's internal environment and “exposures” include all biologically active chemicals within this internal environment.54
Interstitial Lung Diseases and Air Pollution: Narrative Review of Literature
2021, Pulmonary TherapyExposome in IBD: Recent insights in environmental factors that influence the onset and course of IBD
2015, Inflammatory Bowel Diseases