Reviews and PerspectivesReviews in Basic and Clinical Gastroenterology and HepatologyOrganoid Models of Human Gastrointestinal Development and Disease
Reviews in Basic and Clinical Gastroenterology and Hepatology
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Keywords
Gut Organoids
Gastrointestinal Development
Gastrointestinal Regeneration
Gastrointestinal Disease
Abbreviations used in this paper
BE
Barrett’s esophagus
CF
cystic fibrosis
CFTR
cystic fibrosis transmembrane conductance regulator
3D
3-dimensional
DSS
dextran sodium sulfate
ESC
embryonic stem cell
GI
gastrointestinal
IBD
inflammatory bowel disease
iPSC
induced pluripotent stem cell
MIA
multiple intestinal atresia
MVID
microvillus inclusion disease
NEC
necrotizing enterocolitis
NF-κB
nuclear factor κB
PMN
polymorphonuclear leukocytes
PSC
pluripotent stem cell
PUMA
p53 up-regulated modulator of apoptosis
TESI
tissue-engineered small intestine
TGF
transforming growth factor
TLR4
Toll-like receptor 4
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Conflicts of interest The authors disclose no conflicts.
Funding Supported by a National Institutes of Health T32 postdoctoral fellowship from the University of Michigan Center for Organogenesis (T32-HD007505 to P.H.D.), a fellowship from the American College of Surgeons (to P.H.D.), the Intestinal Stem Cell Consortium (U01DK103141 to J.R.S.), a collaborative research project funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Institute of Allergy and Infectious Diseases (NIAID), NIAID grant U19AI116482 (to J.R.S.), and NIDDK grant K01DK091415 (to J.R.S.).