Identifying Molecular Markers for the Early Detection of Pancreatic Neoplasia
Section snippets
Targeting High–Risk Groups for the Early Detection of Pancreatic Neoplasia
Recent studies have demonstrated that many individuals at high-risk of developing pancreatic cancer can be identified based on their family history.13, 15, 16, 17, 18 However, the identification of individuals most at risk of developing pancreatic cancer will be improved once the genetic alterations that predispose to inherited forms of the disease are identified.18, 19, 20, 21, 22, 23, 24, 25, 26
While it is important to target high-risk individuals with a family history of pancreatic cancer,
Recent Developments in Pancreatic Cancer Markers
A large number of protein- and DNA-based markers are under investigation as pancreatic cancer markers. Most of these markers are still in phase I or II studies, that is, their diagnostic potential is still undergoing evaluation and validation.42 Some markers that show promise in differentiating samples from patients with pancreatic cancer from healthy controls fail to distinguish samples arising in the setting of chronic pancreatitis, thereby limiting their diagnostic potential.
Conclusion
In summary, many new protein-, DNA-, and RNA-based markers are under investigation as markers of invasive pancreatic cancer. While some of the newly described markers are promising, many require further validation using optimal laboratory methods and suitable patient populations before they can be considered for use in clinical settings. Since the best chance of cure from pancreatic cancer is when the disease is at an early stage, clinical studies involving pancreatic cancer markers must focus
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Exosomal glypican-1 discriminates pancreatic ductal adenocarcinoma from chronic pancreatitis
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2017, PancreatologyCitation Excerpt :The marker is also inadequate to differentiate between PC and chronic pancreatitis, as up to 40% of the patients with chronic pancreatitis can exhibit elevated levels of CA 19-9 [97,101]. Given its performance characteristics as a biomarker in the general population, serum CA 19-9 is used primarily as a prognostic tool when managing patients with late stage disease, or in monitoring patients for recurrence [97,102]. Considering the genetic markers, Eshleman JR et al., taking into account the possibility that the identification of KRAS mutation in pancreatic fluid analysis might identify microscopic neoplasias in the pancreatic duct system, showed interesting results.
Diagnostic biomarkers for chronic pancreatitis: research progress
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