Endoscopic Appearance of Dysplasia in Ulcerative Colitis and the Role of Staining

 

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Objectives

Cancer Risk and Surveillance

Patients with longstanding extensive ulcerative colitis are at increased risk of developing colorectal cancer. Colonoscopic surveillance is recommended by most authorities in an attempt to reduce the associated mortality. Surveillance relies on the detection of premalignant dysplastic tissue, and where dysplasia is detected, proctocolectomy has historically been and currently remains the management of choice, although there is increasing evidence that adenoma-like dysplastic lesions may safely be resected endoscopically.

Detection of Dysplasia in Ulcerative Colitis

In patients without ulcerative colitis, the premalignant dysplastic lesion, the adenoma, usually occurs as a clearly delineated macroscopically visible abnormality. However, in ulcerative colitis there is no clear-cut adenoma-carcinoma sequence. Dysplasia can occur in polypoid lesions, but often appears as a more subtle mucosal irregularity, or may be macroscopically invisible. Because of this, most endoscopists worldwide take multiple random biopsies of flat mucosa. It has been estimated that 33 biopsies are required to provide a 90 % chance of finding the highest degree of dysplasia present [1]. It has been recommended that four random biopsies per site over nine sites throughout the colon be undertaken, with increased sampling from the rectosigmoid and with additional biopsies from raised or suspicious lesions [2]. However, it is time-consuming to take 30 - 50 nontargeted random biopsies throughout the colon, and dysplastic lesions might still be overlooked.

Recent improvements in endoscopic equipment and technique, particularly the use of dye-sprays (chromoendoscopy), have improved dysplasia detection in ulcerative colitis [3] [4] [5], and reduced the colonoscopist’s dependence on random biopsies. In this report, we describe the endoscopic appearance of dysplasia, and the chromoendoscopic technique for detection of dysplasia in ulcerative colitis.

References

• 1 Rubin C E, Haggitt R C, Burmer G C. et al . DNA aneuploidy in colonic biopsies predicts future development of dysplasia in ulcerative colitis.  Gastroenterology. 1992;  103 1611-620
  PubMedGoogle Scholar
• 2 Bernstein C N. Challenges in designing a randomized trial of surveillance colonoscopy in IBD.  Inflamm Bowel Dis. 1998;  4 132-141
  PubMedGoogle Scholar
• 3 Rutter M D, Saunders B P, Schofield G. et al . Pancolonic indigo carmine dye spraying for the detection of dysplasia in ulcerative colitis.  Gut. 2004;  53 256-260
  CrossrefPubMedGoogle Scholar
• 4 Kiesslich R, Fritsch J, Holtmann M. et al . Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis.  Gastroenterology. 2003;  124 880-888
  CrossrefPubMedGoogle Scholar
• 5 Matsumoto T, Nakamura S, Jo Y. et al . Chromoscopy might improve diagnostic accuracy in cancer surveillance for ulcerative colitis.  Am J Gastroenterol. 2003;  98 1827-1833
  CrossrefPubMedGoogle Scholar
• 6 Morson B C, Pang L S. Rectal biopsy as an aid to cancer control in ulcerative colitis.  Gut. 1967;  8 423-434
  CrossrefPubMedGoogle Scholar
• 7 Blackstone M O, Riddell R H, Rogers B H. et al . Dysplasia-associated lesion or mass (DALM) detected by colonoscopy in long-standing ulcerative colitis: an indication for colectomy.  Gastroenterology. 1981;  80 366-374
  CrossrefPubMedGoogle Scholar
• 8 Kudo S, Tamura S, Nakajima T. et al . Diagnosis of colorectal tumorous lesions by magnifying endoscopy.  Gastrointest Endosc. 1996;  44 8-14
  CrossrefPubMedGoogle Scholar
• 9 Kiesslich R, Neurath M F. Surveillance colonoscopy in ulcerative colitis: magnifying chromoendoscopy in the spotlight.  Gut. 2004;  53 165-167
  CrossrefPubMedGoogle Scholar
• 10 Rutter M, Saunders B, Wilkinson K. et al . Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis.  Gastroenterology. 2004;  126 451-459
  CrossrefPubMedGoogle Scholar
• 11 Olliver J R, Wild C P, Sahay P. et al . Chromoendoscopy with methylene blue and associated DNA damage in Barrett's oesophagus.  Lancet. 2003;  362 373-374
  CrossrefPubMedGoogle Scholar
• 12 Hardie L J, Olliver J R, Wild C P. et al . Chromoendoscopy with methylene blue and the risk of DNA damage.  Gastroenterology. 2004;  126 623-634
  PubMedGoogle Scholar

M. Rutter, MBBS FRCP

University Hospital of North Tees

Hardwick, Stockton-on-Tees, Teesside TS19 8PE, UK ·

Fax: +44-1642-383289

Email: matt.rutter@nth.nhs.uk