Case Studies: Case ReportsA case of mucin-hypersecreting intrahepatic bile duct tumor associated with pancreatic intraductal papillary mucinous tumor☆
Section snippets
Case report
A 60-year-old man presented with complaints of recurrent bouts of epigastric pain and fever. He had been healthy until 2 months before, when he experienced sudden severe continuous epigastric pain for 3 hours. It resolved spontaneously, but after this event he began to have high fevers and persistent epigastric pain. He was a heavy smoker (30 pack years) and consumed alcohol heavily. But he had no history of pulmonary, hepatic, or pancreatic disease. He did not take any medications on a regular
Discussion
Since the first description of IPMT of the pancreas by Ohhashi et al.9 in 1982, a large number of cases have been accumulated. 10, 11, 12, 13, 14, 15 Despite many reports of IPMT of the pancreas, there are few reports of mucin-hypersecreting bile duct tumors in English language publications. 5, 6, 7, 8 These bile duct tumors have had various designations: adenocarcinoma, variants of biliary cystadenocarcinoma, and mucin-hypersecreting papillary cholangiocarcinoma.8 Recently, Kim et al.8 at our
References (20)
- et al.
Pancreatic mucinous ductal ectasia and intraductal papillary neoplasms
Ann Surg
(1997) - et al.
Mucin-producing pancreatic tumors: comparison of MR cholangiopancreatography with endoscopic retrograde cholangiopancreatography
Radiology
(1998) - et al.
Biliary tumors of the liver
Semin Liver Dis
(1995) - et al.(1997)
- et al.
Cystic tumors of the pancreas
Surg Clin North Am
(1995)Cystic neo-plasms and mucin secreting neoplasms
American Gastroenterology
(1998) - et al.
Intraductal papillary-mucinous tumors of the pancreas: clinicopathologic features, outcome, and nomenclature
Gastroenterology
(1996) - et al.
A case of mucus producing cholangiocarcinoma with superficial spread
Jpn J Gastroenterol Surg
(1986) - et al.
Mucin-hypersecreting intrahepatic biliary neoplasms
Radiology
(1988) - et al.
A clinicopathological study of mucus producing bile duct carcinoma [in Japanese]
Nippon Geka Gakkai Zasshi
(1990) - et al.
Mucin-hypersecreting bile duct tumor characterized by the striking homology with an intraductal papillary tumor (IPMT) of the pancreas
Endoscopy
(2000)
Cited by (23)
Synchronous pancreatic adenocarcinoma and intrahepatic cholangiocarcinoma arising in the context of intraductal papillary neoplasms
2016, Clinical ImagingCitation Excerpt :The synchronous occurrence of IPMN and IPN-B is also exceedingly rare. The first such case was described in 2000 [5], and since then, only less than 10 cases have been reported in the literature [6–12]. Of note and relevant to this case, the reported risk of malignant transformation of IPMN is directly related to its site of origin within the ductal system with a risk of progression of 60–92% for main duct IPMN and 6–40% for branch duct IPMN [13–16].
GNAS and KRAS mutational analyses of intraductal papillary neoplasms of the pancreas and bile duct developing in the same individual: A case report
2015, PancreatologyCitation Excerpt :Understanding the molecular mechanism of ductal carcinogenesis will help us to establish more efficient management strategies against these neoplasms. Although several cases of simultaneous resection of IPMN of the pancreas and IPNB have been reported to date [3,4], there is no report of the molecular alterations in both IPMN of the pancreas and IPNB in the same patient. Here, we report a rare patient who developed invasive IPMN of the pancreas as well as IPNB and the results of GNAS/KRAS mutational analyses in these lesions.
Intraductal papillary mucinous tumors of both biliary and pancreatic ducts
2007, Journal of HepatologyA case of mucin hypersecreting intraductal papillary carcinomas occurring simultaneously in liver and pancreas
2005, Gastrointestinal EndoscopyIntraductal papillary neoplasm of the bile duct: The new frontier of biliary pathology
2023, World Journal of Gastroenterology
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Reprint requests: Myung-Hwan Kim, MD, Department of Internal Medicine, Asan Medical Center, 388-1 Poongnap-Dong, Songpa-Gu, Seoul 138-040, Korea; fax 82-2-476-0824; e-mail: [email protected].