Review ArticlesThe possible link between de-worming and the emergence of immunological disease☆
References (22)
- et al.
The other side of the coin: the protective role of the Th2 cytokines
J All Clin Immunol
(2001) - et al.
Geographic origins of Jewish patients with inflammatory bowel disease
Gastroenterology
(1989) - et al.
Epidemiology of inflammatory bowel disease among U.S. military veterans
Gastroenterology
(1991) - et al.
Military history of patients with inflammatory bowel disease: an epidemiological study among U.S. veterans
Am J Gastroenterol
(1998) - et al.
Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10
Lancet
(2000) - et al.
Does the failure to acquire helminthic parasites predispose to Crohn's disease?
FASEB J
(2000) - et al.
Impairment of tetanus toxoid-specific Th1-like immune responses in humans infected with Schistosoma mansoni
J Infect Dis
(1996) - et al.
Infection with Schistosoma mansoni alters Th1/Th2 cytokine responses to a non-parasite antigen
J Immunol
(1992) - et al.
Helminth infection results in decreased virus-specific CD8 cytotoxic T-cell and Th1 cytokine responses as well as delayed virus clearance
Proceedings of the Nat Acad Sci US Am
(1993) - et al.
Modulation of murine cytokine responses to mycobacterial antigens by helminth-induced T helper 2 cell responses
J Immunol
(1993)
Chronic immune activation associated with intestinal helminth infections results in impaired signal transduction and anergy
J Clin Invest
Cited by (70)
Removal of adult cyathostomins alters faecal microbiota and promotes an inflammatory phenotype in horses
2019, International Journal for ParasitologyCitation Excerpt :In the western world there has been a marked rise in immune-mediated diseases in human populations (Weinstock et al., 2002).
Helminth therapy and multiple sclerosis
2013, International Journal for ParasitologyCitation Excerpt :However, it was not until the mid-1990s that investigators seriously considered the possibility that live parasitic worms might be intentionally administered to humans in an attempt to treat autoimmunity or allergy (Weinstock, 2012). These theoretical considerations and feasibility experiments in animals were eventually followed by pilot safety trials in humans with the porcine whipworm, Trichuris suis, in inflammatory bowel disease at the University of Iowa, USA (Weinstock et al., 2002) and the human hookworm, Necator americanus, for asthma at the University of Nottingham, UK (Mortimer et al., 2006). Subsequently, observational studies and exploratory clinical trials have been extended to MS (Table 2).
Trichinella spiralis: Inflammation modulator
2020, Journal of HelminthologyThe role of gastrointestinal pathogens in inflammatory bowel disease: a systematic review
2021, Therapeutic Advances in Gastroenterology
- ☆
Reprint requests: Joel V. Weinstock, MD, Department of Medicine, 4607 JCP, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242. E-mail: [email protected]