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Effects of growth hormone and its secretagogues on bone

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Abstract

The growth hormone (GH)/insulin-like growth factor-1 axis is not only of importance for linear body growth during childhood, but it is also one of the major determinants of adult bone mass. Studies show that GH treatment increases bone mass in rodents as well as in adult GH-deficient humans, but the effect of GH treatment on bone mass in healthy humans has so far not been impressive. Recently, a new class of GH secretagogues (GHSs) has been developed. In humans, GHS treatment affects biochemical markers of bone turnover and increases growth velocity in selected short children with or without GH deficiency. In rodents, GHS treatment increase bone mineral content, but it has not yet been shown that GHS treatment can affect bone mass in adult humans.

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Authors and Affiliations

  1. Department of Physiology, University of Cambridge, Cambridge, UK

    Sabrina Lall & Suzanne L. Dickson

  2. Health Care Discovery, Novo Nordisk A/S, Bagsvaerd, Denmark

    John Rømer & Ian Ahnfelt-Rønne

  3. Research Centre for Endocrinology and Metabolism, Gröna Stråket Sahlgrenska University Hospital, SE-413 45, Göteborg, Sweden

    Johan Svensson, Bengt-Åke Bengtsson, Claes Ohlsson & John-Olov Jansson

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  1. Johan Svensson
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Correspondence to Johan Svensson.

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Svensson, J., Lall, S., Dickson, S.L. et al. Effects of growth hormone and its secretagogues on bone. Endocr 14, 63–66 (2001). https://doi.org/10.1385/ENDO:14:1:063

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  • DOI: https://doi.org/10.1385/ENDO:14:1:063

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