Skip to main content
Log in

Case control study of environmental factors in the etiology of the first attack of acute pancreatitis

A pilot study

  • Published:
International Journal of Pancreatology Aims and scope Submit manuscript

Summary

The aim of this case control study was to assess environmental factors in the etiology of the first attack of acute pancreatitis (AP) in Soweto, South Africa, in the light of modern developments. The study group consisted of 30 patients presenting with a first attack of AP, and 30 healthy age- and gender-matched controls. Fruit intake was found to be a protective factor (odds ratio [OR] 5.3). Crude ORs, although of marginal importance, showed that daily alcohol intake and years of exposure to occupational chemicals may be of significance but would require a much larger study to test these factors. This would be necessary in order to explain the rapid increase in pancreatitis coincident with urbanization and industrialization in the community.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Segal I, Lerios M, Grieve T. Emergence of chronic pancreatitis in a developing country. In: Pancreatitis: Concepts and Classification. Gyr K, Singer MW, Sarles H. eds. Elsevier Science Publishers, Amsterdam 1984; 417–420.

    Google Scholar 

  2. Segal I, Lerios M, MacPhail AP, et al. The genesis of chronic pancreatitis in the South African black population. S Afr Med J 1988; 74: 385–386.

    PubMed  CAS  Google Scholar 

  3. McNamee R, Braganza JM, Hogg J, Leck I, Rose P, Cherry M. Occupational exposure to hydrocarbons and chronic pancreatitis: a case-referent study. Occup Environ Med 194; 51: 631–637.

  4. Braganza JM, ed. The pathogenesis of pancreatitis. Manchester: University Press, 1991.

    Google Scholar 

  5. Uden S, Acheson DWK, Reeves J, et al. Antioxidants, enzymes induction and chronic pancreatitis: a reappraisal following studies in patients on anticonvulsants. Eur J Clin Nutr 1988; 42: 561–569.

    PubMed  CAS  Google Scholar 

  6. Uden S, Schofield D, Miller PF, Dau JP, Bottiglieri T, Braganza JM. Antioxidant therapy for recurrent pancreatitis: biochemical profiles in a placebo controlled trial. Aliment Pharmacol Therap 1992; 6: 229–240.

    Article  CAS  Google Scholar 

  7. Braganza JM, Schofield D, Snehalatha C, Mohan V. Micronutrient antioxidant status in tropieal compare with temperate-zone chronic pancreatitis. Scan J Gastro 1993; 28: 1098–1104.

    Article  CAS  Google Scholar 

  8. Segal I, Gut A, Schofield D, Shiel N, Braganza JM. Micronutrient antioxidant status in black South Africans with chronic pancreatitis: opportunity for prophylaxis. Clin Chim Acta 1995; 239: 71–79.

    Article  PubMed  CAS  Google Scholar 

  9. Van den Heever C. Foreword. Modern Surgery in Africa: The Baragwanath Experience. Southern Book Publishers, Johannesburg. 1988.

    Google Scholar 

  10. Sitas F, Thompson ML. a role for ecological study in the developing world. SAMJ 1993; 83: 753–756.

    PubMed  CAS  Google Scholar 

  11. Braganza JM. The pathogenesis of chronic pancreatitis. QJM 1996; 89: 243–250.

    Google Scholar 

  12. McNamee R, Braganza JM, Hogg J, Leck I, Rose P, Cherry N. Occupational exposure to hydrocarbons and chronic pancreatitis: a case referrant study. Occup Environ Med 1994; 51: 531–537.

    Google Scholar 

  13. Uden S, Acheson DWK, Reeves J, et al. Antioxidants, enzyme induction and chronic pancreatitis: A re-appraisal following studies in patients on anti-convulsants. Eur J Clin Nutr 1988; 42: 561–569.

    PubMed  CAS  Google Scholar 

  14. Segal I, Braganza JM, Gut A, et al. Alcohol, nutritional factors and occupational xenobiotics in chronic pancreatitis: a case control study (abstract). S Afr Med J 1993; 83: A780.

    Google Scholar 

  15. Gut A, Shiel N, Kay PM, Segal I, Braganza JM. Heightened free radical activity in blacks with chronic pancreatitis in Johannesburg, South Africa. Clin Chim Acta 1994; 230: 180–199.

    Article  Google Scholar 

  16. Koop KR, Crump BL, Nordbloom CD, Coon MJ. Immunochemical evidence for induction of the alcohol-oxidising cytochrome P450 or rabbit liver microsomes by diverse agents: ethanol, imidazole, trichloroethylene, acetone, pyrazole and isoniazid. Proc Natl Acad Sci USA 1985; 82: 4065–4069.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Segal, I., Charalambides, D., Becker, P. et al. Case control study of environmental factors in the etiology of the first attack of acute pancreatitis. International Journal of Pancreatology 28, 169–173 (2000). https://doi.org/10.1385/IJGC:28:3:169

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1385/IJGC:28:3:169

Key Words

Navigation