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Licensed Unlicensed Requires Authentication Published by De Gruyter May 19, 2010

The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes

  • Verena Keitel , Christoph Ullmer and Dieter Häussinger
From the journal Biological Chemistry

Abstract

Cholangiocyte cilia are sensory organelles that extend from the apical membrane into the bile duct lumen and detect changes in bile flow and osmolarity. Whether or not cholangiocyte cilia are responsive to bile acids is unknown. TGR5 (Gpbar-1) is a membrane-bound bile acid receptor which is expressed in biliary epithelial cells and promotes chloride secretion in gallbladder epithelial cells. As shown in the present study, TGR5 is localized in the primary cilium of mouse and human cholangiocytes. Here the receptor could play an important role in coupling biliary bile acid concentration and composition to ductular bile formation.


Corresponding author

Received: 2010-3-2
Accepted: 2010-3-23
Published Online: 2010-05-19
Published in Print: 2010-07-01

©2010 by Walter de Gruyter Berlin New York

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