Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Drug-induced Hepatitis with AutoimmuneFeatures during Minocycline Therapy
Masanori AbeShinya FURUKAWAShuzo TAKAYAMAKojiro MlCHITAKAHisaka MlNAMIKazuhisa YAMAMOTONorio HORIIKEMorikazu ONJI
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2003 Volume 42 Issue 1 Pages 48-52

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Abstract

A 25-year-old woman with no history of liver disease developed liver dysfunction associated with severe jaundice and general malaise following a prolonged therapy with minocycline for acne vulgaris. Serumanti-nuclear antibody was detected and immunoglobulin G level was elevated. Symptoms resolved and liver function normalized following minocycline discontinuation and corticosteroid administration. Our diagnosis was drug-induced hepatitis with autoimmune features, as liver histology revealed acute hepatitis. Drug-induced hepatitis should be considered when liver dysfunction or systemic symptoms develops during long-term minocycline therapy.
(Internal Medicine 42: 48-52, 2003)

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© The Japanese Society of Internal Medicine
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