Original ArticleFamilial Association in Adults With Functional Gastrointestinal Disorders
Section snippets
Subjects And Methods
The present study reports results from the third survey of a population-based cohort identified and followed longitudinally since 1988.
Results
A total of 643 (72%) of the 892 eligible subjects returned the survey. The mean age of the responders was 48 years, and 52.4% were female. Women tended to respond more than men (74% vs 70%), and the response rate increased with age. However, older women were less likely to respond than older men (P=.05). The proportions reporting each GI disorder were as follows: 12%, IBS; 14%, dyspepsia; 17%, constipation; 21 %, diarrhea; and 20%, gastroesophageal reflux. Subjects could meet criteria for
Discussion
To our knowledge, this is the first population-based study to identify an association between having IBS and having a first-degree relative with abdominal pain and bowel problems. An association between family history and dyspepsia was detected, but this was not as strong as the association with IBS. An association with diarrhea was detected only after removing subjects with IBS from the group without diarrhea. No association was detected for constipation or reflux alone, but the reporting of a
Acknowledgments
The authors wish to thank Carol T. Van Dyke for her assistance in mailing the surveys, Dixie Tesmer for her assistance with data entry, and Karen A. Kruger for her assistance in preparing the manuscript.
References (27)
The epidemiology of functional gastrointestinal disorders in North America
Gastroenterol Clin North Am
(1996)- et al.
Epidemiology of colonie symptoms and the irritable bowel syndrome
Gastroenterology
(1991) - et al.
Dyspepsia and dyspepsia subgroups: a population-based study
Gastroenterology
(1992) - et al.
Functional constipation and outlet delay: a population-based study
Gastroenterology
(1993) - et al.
Gastrointestinal tract symptoms and self-reported abuse: a population based study
Gastroenterology
(1994) - et al.
Prevalence and clinical spectrum of gastroesophagcal reflux: a population-based study in Olmsted County, Minnesota
Gastroenterology
(1997) - et al.
Risk factors for irritable bowel syndrome: role of analgesics and food sensitivities
Am J Gastroenterol
(2000) - et al.
Irritable bowel syndrome and family history of psychiatric disorder: a preliminary study
Gen Hasp Psychiatry
(1995) - et al.
Health status by gastrointestinal diagnosis and abuse history
Gastroenterology
(1996) - et al.
Evidence of a genetic contribution to functional bowel disorder
Am J Gastroenterol
(1998)
Risk factors associated with symptoms of gastroesophageal reflux
Am I Med
Familial aggregation of gastroesophageal reflux in patients with Barrett's esophagus and esophageal adenocardnoma
Gastroenterology
Irritable bowel syndrome and dyspepsia m the general population: overlap and lack of stability over time
Gastroenterology
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This study was supported in part by grants AG09440 and AR30582 from the National Institutes of Health and by a research grant from Astra-Merck. Dr Locke is the recipient of an American College of Gastroenterology Institute Junior Faculty Development Award.