The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Isolation and Biological Activity of Thielocins: Novel Phospholipase A2 Inhibitors Produced by Thielavia terricola RF-143
KOICHI MATSUMOTO, KAZUSHIGE TANAKA, SHIGERU MATSUTANI, RYUJI SAKAZAKI, HIROSHI HINOO, NOBUO UOTANI, TATSUO TANIMOTO, YOSHIMI KAWAMURA, SHOZO NAKAMOTO, TADASHI YOSHIDA
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JOURNAL FREE ACCESS

1995 Volume 48 Issue 2 Pages 106-112

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Abstract

Thielocins A2α, A2β, A3, B1, B2 and B3 were isolated as a novel family of phospholipase A2 inhibitors from the fermentation broth of Thielavia terricola RF-143 together with thielavins and thielocins A1α and A1β. The most potent inhibitory activity (IC50 = 0.0033μM) against rat group II phospholipase A2 was shown by thielocin A1β. Against human group II phospholipase A2, thielocin B3 (IC50 = 0.076μM) was the most potent.

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The Journal of Antibiotics, Series A

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