Abstract
Most growth factors are released from cells in a form that does not permit immediate interaction with their high affinity receptors. An important mechanism for presentation of these released latent growth factors is activation by the plasminogen activator-plasmin system. The involvement of this system in the biology of Transforming Growth Factor-beta (TGF-beta) is reviewed.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Carrier Proteins / physiology
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Fibrinolysin / physiology*
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Humans
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Intracellular Signaling Peptides and Proteins*
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Latent TGF-beta Binding Proteins
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Plasminogen Activators / physiology*
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Transforming Growth Factor beta / metabolism*
Substances
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Carrier Proteins
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Intracellular Signaling Peptides and Proteins
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Latent TGF-beta Binding Proteins
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Transforming Growth Factor beta
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Plasminogen Activators
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Fibrinolysin