Multiple signals converging on NF-kappaB

Curr Opin Cell Biol. 1999 Apr;11(2):226-32. doi: 10.1016/s0955-0674(99)80030-1.

Abstract

The recent identification of molecular components of the signal transduction pathway regulating activation of nuclear factor-kappaB (NF-kappaB) in response to cytokines such as tumor necrosis factor alpha and interleukin-1beta allows the evaluation of how other diverse stimuli impinge on the NF-kappaB activation pathway. These studies suggest a basis for specificity in activation of specific Rel-related family members and the genetic responses they promote.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinases / physiology
  • DNA-Binding Proteins / physiology
  • Embryonic and Fetal Development
  • Extremities / embryology
  • Gene Expression Regulation / physiology*
  • I-kappa B Proteins
  • Inflammation / physiopathology
  • Mice
  • Mice, Mutant Strains
  • Models, Biological
  • Molecular Sequence Data
  • Morphogenesis
  • NF-kappa B / physiology*
  • Osteoclasts / cytology
  • Protein Kinases / physiology
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Signal Transduction / physiology*
  • Stress, Physiological / physiopathology
  • Transcription, Genetic / physiology*

Substances

  • DNA-Binding Proteins
  • I-kappa B Proteins
  • NF-kappa B
  • Protein Kinases
  • Calcium-Calmodulin-Dependent Protein Kinases