Abstract
The recent identification of molecular components of the signal transduction pathway regulating activation of nuclear factor-kappaB (NF-kappaB) in response to cytokines such as tumor necrosis factor alpha and interleukin-1beta allows the evaluation of how other diverse stimuli impinge on the NF-kappaB activation pathway. These studies suggest a basis for specificity in activation of specific Rel-related family members and the genetic responses they promote.
MeSH terms
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Amino Acid Sequence
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Animals
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Calcium-Calmodulin-Dependent Protein Kinases / physiology
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DNA-Binding Proteins / physiology
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Embryonic and Fetal Development
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Extremities / embryology
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Gene Expression Regulation / physiology*
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I-kappa B Proteins
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Inflammation / physiopathology
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Mice
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Mice, Mutant Strains
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Models, Biological
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Molecular Sequence Data
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Morphogenesis
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NF-kappa B / physiology*
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Osteoclasts / cytology
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Protein Kinases / physiology
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Sequence Alignment
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Sequence Homology, Amino Acid
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Signal Transduction / physiology*
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Stress, Physiological / physiopathology
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Transcription, Genetic / physiology*
Substances
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DNA-Binding Proteins
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I-kappa B Proteins
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NF-kappa B
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Protein Kinases
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Calcium-Calmodulin-Dependent Protein Kinases