Abstract
According to the current paradigm of lymphocyte trafficking, primed B and T cells extravasate in the intestinal lamina propria chiefly by means of the mucosal homing receptor alpha4beta7, which interacts with the vascular addressin MAdCAM-1. However, as discussed here, this mechanism cannot explain the preferential homing of B cells with a high level of J-chain expression to mucosal effector sites outside the gut.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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B-Lymphocytes / immunology*
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B-Lymphocytes / metabolism
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Cell Adhesion Molecules
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Cell Movement / immunology
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Flow Cytometry
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Fluorescent Antibody Technique
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Humans
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Immunity, Mucosal / immunology*
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Immunoglobulin A / biosynthesis
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Immunoglobulin A / metabolism
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Immunoglobulin J-Chains / metabolism
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Immunoglobulins / metabolism
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Integrins / metabolism
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Intestinal Mucosa / immunology
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Mucoproteins / metabolism
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Phenotype
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Receptors, Lymphocyte Homing / immunology
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Receptors, Lymphocyte Homing / metabolism
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Receptors, Lymphocyte Homing / physiology*
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T-Lymphocytes / immunology*
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T-Lymphocytes / metabolism
Substances
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Cell Adhesion Molecules
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Immunoglobulin A
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Immunoglobulin J-Chains
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Immunoglobulins
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Integrins
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MADCAM1 protein, human
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Mucoproteins
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Receptors, Lymphocyte Homing