Abstract
Natural killer (NK) cells can detect whether cells have undergone tumour transformation or viral infection. The discovery of specific inhibitory receptors for major histocompatibility complex class I molecules clarified the basis of this discrimination. However, the receptors responsible for NK-cell triggering in the process of natural cytotoxicity remained elusive until recently. Here, Alessandro Moretta and colleagues describe the identification and characterization of several such receptors.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antigens, CD / immunology
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Aryl Hydrocarbon Hydroxylases*
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CD2 Antigens / immunology
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Cytochrome P-450 Enzyme System / metabolism
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Cytotoxicity, Immunologic / immunology*
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Humans
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Killer Cells, Natural / metabolism
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Killer Cells, Natural / physiology*
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Lectins, C-Type*
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Ligands
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Membrane Glycoproteins / immunology
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NK Cell Lectin-Like Receptor Subfamily D
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Natural Cytotoxicity Triggering Receptor 2
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Receptors, Immunologic / chemistry
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Receptors, Immunologic / metabolism
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Receptors, Immunologic / physiology*
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Receptors, Natural Killer Cell
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Steroid Hydroxylases / metabolism
Substances
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Antigens, CD
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CD2 Antigens
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Lectins, C-Type
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Ligands
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Membrane Glycoproteins
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NCR2 protein, human
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NK Cell Lectin-Like Receptor Subfamily D
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Natural Cytotoxicity Triggering Receptor 2
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Receptors, Immunologic
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Receptors, Natural Killer Cell
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Cytochrome P-450 Enzyme System
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Steroid Hydroxylases
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Aryl Hydrocarbon Hydroxylases
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steroid 15-alpha-hydroxylase