Abstract
Background:
A nonrandomized trial of Helicobacter pylori eradication was conducted in patients with endoscopically diagnosed gastric adenoma to determine the long-term effect of antimicrobial treatment on progression of the adenoma.
Methods:
Of 64 patients with an endoscopically diagnosed gastric adenoma and H pylori infection, 32 were treated with omeprazole and antibiotics to eradicate the infection, and 32 were not.
Results:
During 2 years of follow-up, 4 (12.5%) of the 32 patients in the untreated group developed an early stage, intestinal-type gastric cancer, whereas no gastric cancer was found in the 32 patients in the treated group.
Conclusion:
H Pylori eradication may inhibit progression of gastric adenoma to carcinoma.
Publication types
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Clinical Trial
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Controlled Clinical Trial
MeSH terms
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Adenoma / diagnosis
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Adenoma / microbiology
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Adenoma / pathology*
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Aged
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Aged, 80 and over
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Amoxicillin / administration & dosage*
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Carcinoma / diagnosis
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Carcinoma / epidemiology
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Carcinoma / microbiology
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Carcinoma / pathology
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Cell Transformation, Neoplastic / pathology*
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Clarithromycin / administration & dosage*
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Drug Therapy, Combination
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Female
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Gastric Mucosa / pathology
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Gastroscopy
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Helicobacter Infections / diagnosis
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Helicobacter Infections / drug therapy*
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Helicobacter pylori / drug effects*
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Helicobacter pylori / isolation & purification
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Humans
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Incidence
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Male
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Omeprazole / administration & dosage*
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Probability
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Reference Values
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Statistics, Nonparametric
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Stomach Neoplasms / diagnosis
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Stomach Neoplasms / epidemiology
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Stomach Neoplasms / microbiology
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Stomach Neoplasms / pathology*
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Treatment Outcome
Substances
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Amoxicillin
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Clarithromycin
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Omeprazole