Abstract
Antibiotic-treated mice orally inoculated with one of three Candida albicans strains (including two mutant strains) or indigenous Candida pelliculosa showed levels of candidal gastrointestinal colonization that were strain specific. However, regardless of strain, the numbers of viable candida were intermediate to high in the stomach, were consistently lowest in the upper small intestine, and increased progressively down the intestinal tract.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / therapeutic use
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Bacitracin / administration & dosage
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Bacitracin / therapeutic use
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Candida albicans / enzymology
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Candida albicans / genetics
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Candida albicans / physiology
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Candidiasis / microbiology*
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Candidiasis / pathology
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Digestive System / microbiology*
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Disease Models, Animal
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Female
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Fungal Proteins / genetics
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Fungal Proteins / metabolism
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Gentamicins / administration & dosage
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Gentamicins / therapeutic use
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HeLa Cells
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Humans
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Mice
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Mutation*
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Orotidine-5'-Phosphate Decarboxylase / genetics
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Orotidine-5'-Phosphate Decarboxylase / metabolism
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Streptomycin / administration & dosage
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Streptomycin / therapeutic use
Substances
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Anti-Bacterial Agents
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Fungal Proteins
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Gentamicins
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Bacitracin
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Orotidine-5'-Phosphate Decarboxylase
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Streptomycin