Abstract
Wild-type p53 competitively binds to the promoter region of COX-2 in vitro and inhibits its transcription. We examined the association between p53 mutation and COX-2 expression in gastric cancer. COX-2 over-expression was seen in 19 (48.7%) cases. These tumours had more lymph-node metastasis (P = 0.048) and tended to have a poorer survival (P = 0.07). Missense mutations of p53 were detected in 20 (51.3%) patients and had a significantly stronger COX-2 expression than tumours without p53 mutation (P = 0.016). Our results suggest a link between p53 mutation and COX-2 overexpression in gastric cancer.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Cyclooxygenase 2
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DNA / chemistry
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DNA / genetics
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DNA Mutational Analysis
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Female
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Humans
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Immunohistochemistry
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Isoenzymes / biosynthesis*
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Male
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Membrane Proteins
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Middle Aged
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Mutation, Missense
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Polymorphism, Single-Stranded Conformational
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Prostaglandin-Endoperoxide Synthases / biosynthesis*
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Stomach Neoplasms / enzymology
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Stomach Neoplasms / genetics
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Stomach Neoplasms / pathology*
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Survival Analysis
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Tumor Suppressor Protein p53 / genetics*
Substances
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Isoenzymes
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Membrane Proteins
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Tumor Suppressor Protein p53
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DNA
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Cyclooxygenase 2
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PTGS2 protein, human
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Prostaglandin-Endoperoxide Synthases